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Wednesday, October 28, 2026 ยท WOMEN'S EDITION
LongevityMorning
What's new in feeling better and living longer. 5-minute read.
Good morning. Today: the first generic of a weekly combination hormone patch, a trial pairing an eating window with exercise, and the first national count of "food noise."
01 ยท HORMONES ยท MENOPAUSE
FDA approved the first generic weekly combination HRT patch
The FDA approved Zydus Pharmaceuticals' generic version of Climara Pro, a once-weekly patch combining estradiol and levonorgestrel, on Oct. 19.
Why it matters: Many women have reported trouble filling estrogen patch prescriptions this year, and this is the first generic of this combination patch.
The details: It's approved for women with a uterus to treat moderate to severe hot flashes and night sweats and to help prevent postmenopausal osteoporosis. The progestin lowers the risk of uterine lining overgrowth that estrogen alone can cause. Medical Daily reported the FDA rated it therapeutically equivalent to the brand.
Yes, but: No launch date has been announced, and the FDA directs patients to Zydus for availability. It won't ease shortages of estrogen-only patches, which women without a uterus typically use. Bayer expects supply constraints on one Climara estradiol patch dose until early 2027, according to Reuters as cited by Medical Daily. Talk to your doctor.
Source: FDA ยท Medical Daily
02 ยท WEIGHT LOSS ยท TRAINING
An eating window plus exercise cut more body fat, but the edge faded in a year
In a 12-week Spanish trial of 187 adults with obesity, about half of them women, combining an eight-hour eating window with supervised exercise led to more body fat loss than standard care or exercise alone.
Why it matters: Time-restricted eating and pairing it with strength and interval training are both popular, and this trial tested them head to head.
The details: Participants were randomized to standard care, time-restricted eating, supervised exercise (strength plus high-intensity aerobic training) or both. Both eating-window groups lost about 2.2 kg (roughly 5 lb) more than standard care. Among those with fatty liver at the start, about 30% of the combined group no longer met the criteria vs. 6.5% with standard care.
Yes, but: Liver fat, the main outcome, fell in all four groups with no significant differences between them. An exploratory extra drop in liver fat was seen in men but not women. At one-year follow-up, the weight and body composition differences were gone. Published in Nature Communications (the TEMPUS trial); funded by Spanish government and EU grants.
03 ยท APPETITE ยท WEIGHT
Up to 1 in 10 U.S. adults reported "food noise" in a first national estimate
A survey of 3,646 U.S. adults found that 4% to 9.5% met criteria for "food noise," persistent and unwanted thoughts about food, depending on the definition used, and women scored higher than men.
Why it matters: The phrase is everywhere in weight-loss conversations, but there's been little data on how common it actually is.
The details: Drexel University and UC Irvine researchers used a five-item questionnaire in a nationally representative panel, excluding current GLP-1 users. Among adults with obesity, 6% to 13.7% met the criteria. Scores were also higher in people with higher BMI and in adults under 60.
Yes, but: "A greater proportion of adults with obesity met the criteria, but most did not," the authors wrote. No clinically validated threshold exists, the survey is a one-time snapshot, and the study is a preprint under review at the International Journal of Obesity, not yet peer reviewed.
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New Oct. 27, breast oncologist Dr. Eleonora Teplinsky on who may be a candidate for hormone therapy after breast cancer or with a family history, plus vaginal estrogen and DHEA for survivors.
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The Model Health Show: The Hard Truth About Sexual Fitness | Dr. Rena Malik
Out Oct. 25, urologist and pelvic surgeon Dr. Rena Malik on how diet, exercise, sleep and stress affect sexual health, including hormones and pelvic floor strength.
Quick Hits
Where GLP-1s come from. In a not-yet-peer-reviewed survey of 9,150 U.S. adults, GLP-1 use rose from 8.2% to 12% between March 2024 and October 2025, and about a third of users got the drugs through online providers, med spas, compounding or foreign pharmacies, or without a prescription. News-Medical
Activity and depression genes. In NIH All of Us data combining genetics and Fitbit records, genetic risk was less strongly linked to depression severity among adults who took more steps or logged more moderate-to-vigorous activity, per a study in Nature Mental Health. News-Medical
Mediterranean diet microproteins. In a small observational USC study, older adults who followed the Mediterranean diet more closely had higher blood levels of humanin and SHMOOSE, mitochondrial microproteins being studied for heart and brain health; it can't show cause and effect. ScienceDaily
See you tomorrow morning.
LongevityMorning is for informational purposes only and isn't medical advice.