Friday, October 2, 2026 · MEN'S EDITION
LongevityMorning
What's new in feeling better and living longer. 5-minute read.
Good morning. Today: a new creatine trial in adults 45 to 65, the fight over compounded peptides, and a study flagging a popular joint supplement.
01 · SUPPLEMENTS
Creatine built muscle in middle-aged adults, even without workouts
A 12-week randomized trial found creatine added lean mass and strength in adults 45 to 65, even in people who didn't exercise.
Why it matters: Creatine is one of the most popular supplements on the shelf, and most research has focused on young athletes, not middle-aged adults.
The details: 64 adults completed the Texas A&M trial, published in the Journal of the International Society of Sports Nutrition. Without exercise, the creatine group gained about 2.4 lbs of lean tissue and got stronger on leg and bench press.
With exercise, creatine users saw bigger strength gains and longer time to exhaustion. Paired with a reduced-calorie diet and exercise, creatine added nearly 3 lbs of lean tissue while participants lost fat.
Yes, but: Creatine didn't improve aerobic capacity beyond exercise alone. The trial was short, limited to middle-aged adults, and funded by the WoodNext Foundation through the Texas A&M Foundation.
Source: ScienceDaily
02 · PEPTIDES
The battle over compounded peptides like BPC-157
The fight over whether pharmacies can legally compound peptides like BPC-157 is heating up.
Why it matters: Peptides have exploded in popularity, and the rules decide whether you get them from a pharmacy with a prescription or from the gray market.
The details: In July, an FDA advisory committee voted to recommend six peptides for the list that lets compounding pharmacies make them. FDA staff scientists unanimously opposed it, citing no human clinical data for 4 of the 7 peptides nominated.
AJMC reports BPC-157 and ipamorelin were removed from the FDA's restricted list by April, after HHS Secretary Kennedy's February announcement.
Yes, but: State rules still vary. Connecticut, Alabama, New York, California, Massachusetts and Louisiana restrict peptide compounding; Texas, Florida, Nevada and Arizona are more permissive. Most of these peptides lack human trials, so talk to your doctor.
Source: AJMC
03 · BRAIN HEALTH
A popular joint supplement linked to faster memory decline
Glucosamine, a common joint supplement, was linked to faster progression of memory decline in a new study.
Why it matters: It's sold over the counter and widely taken for joint pain, often by the same age group at risk for dementia.
The details: UF Health researchers analyzed records from 1,896 people with Alzheimer's and related dementias and 2,750 with mild cognitive impairment, published in Nature Metabolism. About 8% of each group took glucosamine.
Users had a 25% higher likelihood of mild impairment progressing to dementia, and a 25% higher risk of death among those already diagnosed. Mice given glucosamine did worse on a social memory test.
Yes, but: It's an association, not proof. Co-author Matt Gentry called the results "very provocative," and the authors say clinical trials are needed.
Source: ScienceDaily
RESOURCES · TOOLS WE LOVE
Longevity resources
Thorne Creatine
Creatine monohydrate powder, 90 servings.
Function Health
Annual membership with 160+ lab tests and doctor-reviewed results.
Hone Health
Telehealth clinic for biomarker testing and clinician-guided hormone care.
WATCH, LISTEN, SCROLL · THE BEST OF THE WEEK
Can't Miss Longevity Content
The videos, posts and podcasts everyone's talking about.
YOUTUBE VIDEO
Huberman Lab: What Humans, Animals & Plants Tell Us About Consciousness | Michael Pollan
Pollan on psychedelics, the microbiome, caffeine and the body-brain conversation that shapes how you feel (Sept 28).
PODCAST
Huberman Lab Essentials: Tools to Improve Your Focus & Concentration
A tight rundown of the science of attention, from sleep and caffeine to meditation and work blocks (Oct 1).
ARTICLE
STAT: GLP-1s are getting a lifestyle-brand makeover
How Novo Nordisk and Eli Lilly are marketing weight-loss drugs to "customers" instead of patients (Sept 28).
ARTICLE
Medical News Today: How your daily drink may affect your mental health
A 59-study, 2 million-person review on sugary drinks, coffee and depression risk, with the caveats (Sept 30).
Quick Hits
Coffee and your gut. In a 62-person trial, both regular and decaf changed gut bacteria and were linked to lower stress; the study was funded by a coffee-industry group. ScienceDaily
Urolithin A and the heart. The pomegranate-derived compound, already sold as a supplement, improved heart function by up to 80% in animal models; no human heart trials yet. ScienceDaily
New Alzheimer's blood tests. Two FDA-cleared tests, including one for symptomatic adults as young as 40, are meant to support a doctor's evaluation, not screen healthy people. Medical News Today
A slow jog for your brain. A 10-minute easy jog improved mood and reaction times in 24 young adults in a small crossover study. Medical News Today
See you tomorrow morning.
LongevityMorning is for informational purposes only and isn't medical advice.