The details: Both retatrutide doses cut A1C by 2.2 points from an average of 8.3%, vs. 1.8 points with semaglutide. Starting weight averaged about 226 lb, so that's roughly 44 to 47 lb lost on retatrutide vs. 21 lb on semaglutide. Non-HDL cholesterol, triglycerides and systolic blood pressure also improved more on retatrutide.

Yes, but: These are topline results from the drugmaker, not yet peer reviewed, and the trial was open-label. Quitting due to side effects was more common on retatrutide (4.8% and 7.9%) than semaglutide (2.7%), and stomach side effects were most common in all groups. No approval timeline was given. Talk to your doctor.

The details: Participants averaged 37.4 years old, had normal to high-normal blood pressure and weren't on blood pressure medication. After four weeks of training, groups continued three, two or one times a week, or stopped. Systolic pressure ended 6.95 mmHg lower than at the start in the twice-weekly group and 6.56 mmHg lower in the once-weekly group. Published in BMJ Open Sport & Exercise Medicine.

Yes, but: In the group that stopped, the improvements reversed and were no different from the control group by the end. The maintenance phase lasted only four weeks, and the researchers said longer studies are needed. The summary didn't report funding or a breakdown by sex.

The details: The team, led by Glen Pridham of Israel's Weizmann Institute, used a computational method to separate chronological age from reproductive timing. Anti-Müllerian hormone and estradiol began falling rapidly about 15 and 12 years before the final period, and FSH began rising faster about 14 years before. Men didn't show similar abrupt shifts. Menopausal hormone therapy was associated with smaller changes in many measures, especially bone, liver and kidney function.

Yes, but: The study is observational, used retrospective records and relied on self-reported menopause timing, and the hormone therapy link needs confirmation, the journal's press release noted. The summaries didn't report how large the changes were. The University of Melbourne's Martha Hickey, who wasn't involved, said the word "cliff" is "potentially alarming for women" and implies a decline "which this study does not demonstrate." Talk to your doctor.

Lifting after 60. In a 12-week randomized trial of 60 adults aged 60 to 75 in Brazil, 41 of them women, supervised resistance training improved breathing-muscle strength, grip strength and sit-to-stand performance vs. a no-exercise group and lowered the inflammation marker IL-6, per the Journal of Functional Morphology and Kinesiology. JFMK

Sauna and immune cells. In 51 adults averaging 50 years old, one 30-minute sauna session with a cold shower midway briefly raised every type of white blood cell measured, with neutrophils and lymphocytes back to baseline within 30 minutes; the University of Eastern Finland researchers said it doesn't show a lasting immune benefit. ScienceDaily

Daylight and dementia. Among 87,577 adults who wore wrist sensors and were followed a median of 8.1 years, average daytime light above 1,000 lux was tied to a 16% lower dementia risk, per General Psychiatry; the study shows an association only. ScienceDaily

Naps and dementia. In 995 Medicare beneficiaries 65 and older followed up to 10 years, napping most days or every day was tied to a 48% higher dementia risk; experts quoted said that doesn't mean napping causes dementia. Medical News Today